HTR6 and PARP8

Data Source:
BioGRID (two hybrid)

		HTR6	PARP8
Description		5-hydroxytryptamine receptor 6	poly(ADP-ribose) polymerase family member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse	Intracellular Anatomical Structure
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity	NAD+ ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Protein ADP-ribosylation Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Nicotinamide salvaging Maturation of nucleoprotein Maturation of nucleoprotein
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Callous-unemotional behaviour ( 23874384) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood ear infection ( 27182965) General risk tolerance (MTAG) ( 30643258) HOMA-B (corrected for HOMA-IR) ( 30369944) Myopia (pathological) ( 22685421) Type 2 diabetes ( 32499647 30718926) Verbal declarative memory ( 25648963)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	1 interacting genes: HTR6
Entrez ID		3362	79668
HPRD ID		03066	07960
Ensembl ID		ENSG00000158748	ENSG00000151883
Uniprot IDs		P50406	B2RB27 E9PFI7 Q8N3A8
PDB IDs
Enriched GO Terms of Interacting Partners?
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