ATXN10 and GNB2

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo, two hybrid)

		ATXN10	GNB2
Description		ataxin 10	G protein subunit beta 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm	Extracellular Space Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Vesicle Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Binding Identical Protein Binding	GTPase Activity Calcium Channel Regulator Activity Protein Binding G-protein Gamma-subunit Binding Protein-containing Complex Binding GTPase Binding
	Biological Process	Nervous System Development Neuron Projection Development Cilium Assembly	Protein Folding G Protein-coupled Receptor Signaling Pathway
Pathways			Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hip circumference ( 28552196) Waist circumference ( 28552196)	Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)
Interacting Genes		12 interacting genes: ABCA1 FN1 GLS GNB1 GNB2 GOLGA1 HSPB1 HTR6 LIMS1 MRPS16 PPP1R12A PTGER4	33 interacting genes: ANXA7 ATXN10 CAPNS1 CDKN1A CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 GRK2 GSK3B ID3 MTNR1B NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1
Entrez ID		25814	2783
HPRD ID		04624	11820
Ensembl ID		ENSG00000130638	ENSG00000172354
Uniprot IDs		Q9UBB4	P62879 Q6FHM2
PDB IDs
Enriched GO Terms of Interacting Partners?
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