HTR6 and AKR1A1

Data Source:
BioGRID (two hybrid)

		HTR6	AKR1A1
Description		5-hydroxytryptamine receptor 6	aldo-keto reductase family 1 member A1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse	Extracellular Space Cytosol Apical Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Protein Binding Electron Transfer Activity Allyl-alcohol Dehydrogenase Activity L-glucuronate Reductase Activity Glucuronolactone Reductase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Glucose Metabolic Process Cellular Aldehyde Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate L-ascorbic Acid Biosynthetic Process Electron Transport Chain D-glucuronate Catabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Glutathione Derivative Biosynthetic Process
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Glutathione conjugation Formation of xylulose-5-phosphate
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil	Tolrestat Nicotinamide adenine dinucleotide phosphate Copper
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 32888494 27863252) Pulse pressure ( 30224653 30578418) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	4 interacting genes: EXOSC4 HTR6 TERF1 TERF2IP
Entrez ID		3362	10327
HPRD ID		03066	00069
Ensembl ID		ENSG00000158748	ENSG00000117448
Uniprot IDs		P50406	P14550 V9HWI0
PDB IDs			2ALR
Enriched GO Terms of Interacting Partners?
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