ACVRL1 and GDF2

Data Source:
BioGRID (pull down, pull down)

		ACVRL1	GDF2
Description		activin A receptor like type 1	growth differentiation factor 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex BMP Receptor Complex	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity	Cytokine Activity Protein Binding Growth Factor Activity
	Biological Process	Angiogenesis Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Endocardial Cushion Morphogenesis Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Dorsal Aorta Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Focal Adhesion Assembly Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Endocardial Cushion To Mesenchymal Transition Negative Regulation Of DNA Biosynthetic Process	Ossification Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Cartilage Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process
Pathways		Signaling by BMP	Signaling by BMP
Drugs		ATP
Diseases		Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Hematocrit ( 29403010) Hemoglobin ( 29403010 32888494) Hemoglobin levels ( 32327693) Lymphocyte counts ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Urate levels ( 23263486) White blood cell count ( 32888494 27863252)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 30224653)
Interacting Genes		13 interacting genes: ACVR2A BAMBI CSNK2B FKBP1A GDF2 SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP	6 interacting genes: ACVR1 ACVR2A ACVR2B ACVRL1 BMPR2 ENG
Entrez ID		94	2658
HPRD ID		03181	05492
Ensembl ID		ENSG00000139567	ENSG00000263761
Uniprot IDs		A0A0S2Z310 P37023	B2RC63 Q9UK05
PDB IDs		2LCR 3MY0 4FAO 6SF1 6SF2 6SF3	1ZKZ 4FAO 4MPL 4YCG 4YCI 5HZW 5I05
Enriched GO Terms of Interacting Partners?
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