ANXA3 and UBR1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ANXA3	UBR1
Description		annexin A3	ubiquitin protein ligase E3 component n-recognin 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Dendrite Phagocytic Vesicle Membrane Specific Granule Neuronal Cell Body Extracellular Exosome	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Calcium Ion Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Calcium-dependent Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	Phagocytosis Positive Regulation Of Endothelial Cell Migration Hippocampus Development Animal Organ Regeneration Defense Response To Bacterium Negative Regulation Of Catalytic Activity Neutrophil Degranulation Positive Regulation Of Angiogenesis Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Response To Glucocorticoid Response To Growth Factor	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fluocinolone acetonide Ethanolamine Difluocortolone
Diseases			Johanson-Blizzard syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Metabolite levels ( 23823483) Non-albumin protein levels ( 22558069) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 22446963)	MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		6 interacting genes: EMG1 IGSF21 REG3A TP53 UBR1 UNC119	28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		306	197131
HPRD ID		00111	09342
Ensembl ID		ENSG00000138772	ENSG00000159459
Uniprot IDs		P12429	Q8IWV7
PDB IDs		1AII 1AXN	3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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