GLO1 and PJA1

Data Source:
BioGRID (enzymatic study)

		GLO1	PJA1
Description		glyoxalase I	praja ring finger ubiquitin ligase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Cytoplasm
	Molecular Function	Lactoylglutathione Lyase Activity Protein Binding Zinc Ion Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Carbohydrate Metabolic Process Pyruvate Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process	Protein Ubiquitination Protein Catabolic Process
Pathways		Pyruvate metabolism	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-hydroxy-N-iodophenylcarbamoyl)glutathione Mercaptoethanol S-benzylglutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Diseases
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 29317602) Restless legs syndrome ( 29029846)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		4 interacting genes: IKBKG MAP3K13 MEOX2 PJA1	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		2739	64219
HPRD ID		00730	02335
Ensembl ID		ENSG00000124767	ENSG00000181191
Uniprot IDs		Q04760 X5DNM4	Q8NG27
PDB IDs		1BH5 1FRO 1QIN 1QIP 3VW9 3W0T 3W0U	2L0B
Enriched GO Terms of Interacting Partners?
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