GDF9 and TDGF1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GDF9	TDGF1
Description		growth differentiation factor 9	teratocarcinoma-derived growth factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft
	Molecular Function	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding
	Biological Process	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway SMAD Protein Signal Transduction Regulation Of Progesterone Secretion	Activation Of MAPK Activity Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Somatic Stem Cell Population Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways			Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		Asthma ( 31619474)	Blood protein levels ( 29875488 28240269) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		45 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3 WASHC3	22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2
Entrez ID		2661	6997
HPRD ID		03560	01757
Ensembl ID		ENSG00000164404	ENSG00000241186
Uniprot IDs		B4DXG3 O60383	F5H1T8 P13385
PDB IDs
Enriched GO Terms of Interacting Partners?
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