TDGF1 and BAG6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TDGF1	BAG6
Description		teratocarcinoma-derived growth factor 1	BAG cochaperone 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome BAT3 Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Misfolded Protein Binding Proteasome Binding Ubiquitin-specific Protease Binding
	Biological Process	Activation Of MAPK Activity Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Somatic Stem Cell Population Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Kidney Development Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Ubiquitin-dependent ERAD Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress ER-associated Misfolded Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Maintenance Of Unfolded Protein Involved In ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Metabolite levels ( 23823483) Refractive error ( 32231278)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Height ( 28552196) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	118 interacting genes: ACVR1B AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CHN2 CILK1 CLU CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GET4 GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT IQCG KLHL12 KPNA2 LBP MAPK6 MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TDGF1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL4B UBL7 UBQLN1 UBQLN2 UBQLN4 USP13 VAMP2 XRN1 ZFYVE9
Entrez ID		6997	7917
HPRD ID		01757	00808
Ensembl ID		ENSG00000241186	ENSG00000204463
Uniprot IDs		F5H1T8 P13385	A0A1U9X7A6 P46379
PDB IDs			1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8
Enriched GO Terms of Interacting Partners?
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