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GDF9 and RAB27A
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
GDF9
RAB27A
Description
growth differentiation factor 9
RAB27A, member RAS oncogene family
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Cytoplasm
Photoreceptor Outer Segment
Extracellular Region
Lysosome
Late Endosome
Golgi Apparatus
Cytosol
Apical Plasma Membrane
Secretory Granule
Dendrite
Secretory Granule Membrane
Multivesicular Body Membrane
Weibel-Palade Body
Melanosome Membrane
Specific Granule Lumen
Melanosome
Extracellular Exosome
Exocytic Vesicle
Molecular Function
Cytokine Activity
Growth Factor Activity
Type I Activin Receptor Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Domain Specific Binding
Myosin V Binding
Biological Process
Oocyte Growth
Transforming Growth Factor Beta Receptor Signaling Pathway
Female Gamete Generation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Cell Growth
BMP Signaling Pathway
SMAD Protein Signal Transduction
Regulation Of Progesterone Secretion
Protein Targeting
Exocytosis
Blood Coagulation
Positive Regulation Of Gene Expression
Antigen Processing And Presentation
Melanocyte Differentiation
Melanosome Localization
Melanosome Transport
Multivesicular Body Organization
Neutrophil Degranulation
Cytotoxic T Cell Degranulation
Natural Killer Cell Degranulation
Positive Regulation Of Exocytosis
Synaptic Vesicle Transport
Positive Regulation Of Phagocytosis
Multivesicular Body Sorting Pathway
Complement-dependent Cytotoxicity
Positive Regulation Of Regulated Secretory Pathway
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Positive Regulation Of Constitutive Secretory Pathway
Exosomal Secretion
Pathways
Insulin processing
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS
Asthma (
31619474
)
Fractional exhaled nitric oxide levels (
25431337
)
Glioma (
30714141
)
Interacting Genes
45 interacting genes:
ACVR2A
ADPGK
ANXA7
APLP1
BMP15
BMPR1A
BMPR1B
BMPR2
BTBD2
CDKN1A
CDKN2C
CRELD1
DLEU1
DNM2
FOXG1
FXYD6
GADD45G
ILF3
KDM1A
KIF22
LSM3
MOB4
MPHOSPH6
MYCBP
NDUFB9
ORAI2
PABPC4
PAFAH1B3
PCDHA4
PCYT2
PMF1
PRKRA
PSMD11
RAB27A
RSRC1
S100A8
SAT1
SERPINB9
SMN1
SNRPG
STRN4
TDGF1
TK1
TRIB3
WASHC3
28 interacting genes:
ADRB2
APP
CEP126
COPS6
EEF1A1
ERG28
EXPH5
GDF9
GDI1
GZMB
LRIF1
MLPH
MYO5A
MYRIP
RABGGTB
RBM48
RIMS1
RIMS2
RPH3A
RPH3AL
STX1A
SYTL1
SYTL2
SYTL3
SYTL4
SYTL5
UNC13D
ZBTB16
Entrez ID
2661
5873
HPRD ID
03560
04845
Ensembl ID
ENSG00000164404
ENSG00000069974
Uniprot IDs
B4DXG3
O60383
A2RU94
P51159
PDB IDs
6HUF
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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