TDGF1 and GDF3

Data Source:
BioGRID (pull down)

		TDGF1	GDF3
Description		teratocarcinoma-derived growth factor 1	growth differentiation factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft	Extracellular Space Cytoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	Cytokine Activity Growth Factor Activity Protein Kinase Binding
	Biological Process	Activation Of MAPK Activity Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Somatic Stem Cell Population Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Skeletal System Development Eye Development Regulation Of Cell Fate Commitment Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation SMAD Protein Signal Transduction
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Klippel-Feil syndrome(KFS)
GWAS		Blood protein levels ( 29875488 28240269) Metabolite levels ( 23823483) Refractive error ( 32231278)	Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	1 interacting genes: TDGF1
Entrez ID		6997	9573
HPRD ID		01757	05938
Ensembl ID		ENSG00000241186	ENSG00000184344
Uniprot IDs		F5H1T8 P13385	Q9NR23
PDB IDs
Enriched GO Terms of Interacting Partners?
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