TDGF1 and ACVR2B

Data Source:
BioGRID (pull down)

		TDGF1	ACVR2B
Description		teratocarcinoma-derived growth factor 1	activin A receptor type 2B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Activation Of MAPK Activity Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Somatic Stem Cell Population Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Blood protein levels ( 29875488 28240269) Metabolite levels ( 23823483) Refractive error ( 32231278)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	21 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1
Entrez ID		6997	93
HPRD ID		01757	04106
Ensembl ID		ENSG00000241186	ENSG00000114739
Uniprot IDs		F5H1T8 P13385	Q13705
PDB IDs			2H62 2QLU 4FAO 5NGV 5NHR
Enriched GO Terms of Interacting Partners?
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