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GDF9 and BMPR2
Data Source:
HPRD
(in vivo)
GDF9
BMPR2
Description
growth differentiation factor 9
bone morphogenetic protein receptor type 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Cytoplasm
Extracellular Space
Nucleoplasm
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Adherens Junction
Basal Plasma Membrane
Cell Surface
Postsynaptic Density
Apical Plasma Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
Spanning Component Of Plasma Membrane
Molecular Function
Cytokine Activity
Growth Factor Activity
Type I Activin Receptor Binding
Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Protein Binding
ATP Binding
Activin Receptor Activity, Type II
Growth Factor Binding
BMP Binding
Cadherin Binding
Metal Ion Binding
BMP Receptor Activity
Protein Tyrosine Kinase Binding
Biological Process
Oocyte Growth
Transforming Growth Factor Beta Receptor Signaling Pathway
Female Gamete Generation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Cell Growth
BMP Signaling Pathway
SMAD Protein Signal Transduction
Regulation Of Progesterone Secretion
Blood Vessel Development
Mesoderm Formation
Maternal Placenta Development
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lymphangiogenesis
Blood Vessel Remodeling
Chondrocyte Development
Negative Regulation Of Systemic Arterial Blood Pressure
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Development
Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Brain Development
Cellular Response To Starvation
Anterior/posterior Pattern Specification
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Lung Blood Pressure
Proteoglycan Biosynthetic Process
Negative Regulation Of Cell Growth
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Activin Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Vasoconstriction
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Cardiac Muscle Tissue Development
Positive Regulation Of Axon Extension Involved In Axon Guidance
Limb Development
Endochondral Bone Morphogenesis
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Positive Regulation Of Cartilage Development
Retina Vasculature Development In Camera-type Eye
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Endothelial Cell Apoptotic Process
Negative Regulation Of Chondrocyte Proliferation
Semi-lunar Valve Development
Negative Regulation Of DNA Biosynthetic Process
Pathways
Signaling by BMP
Drugs
Dibotermin alfa
Fostamatinib
Diseases
GWAS
Asthma (
31619474
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
PR interval (
32439900
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32203549
32154731
)
Urate levels (
23263486
)
Interacting Genes
45 interacting genes:
ACVR2A
ADPGK
ANXA7
APLP1
BMP15
BMPR1A
BMPR1B
BMPR2
BTBD2
CDKN1A
CDKN2C
CRELD1
DLEU1
DNM2
FOXG1
FXYD6
GADD45G
ILF3
KDM1A
KIF22
LSM3
MOB4
MPHOSPH6
MYCBP
NDUFB9
ORAI2
PABPC4
PAFAH1B3
PCDHA4
PCYT2
PMF1
PRKRA
PSMD11
RAB27A
RSRC1
S100A8
SAT1
SERPINB9
SMN1
SNRPG
STRN4
TDGF1
TK1
TRIB3
WASHC3
52 interacting genes:
ACTR8
ACVR1
ACVR1B
ARSA
BMP10
BMP2
BMP4
BMP6
BMP7
BMPR1A
BMPR1B
C4BPA
CCDC89
CES1
CRYAB
CTBP1
DYNLT1
FHL2
FOXL1
FRS3
GDF2
GDF5
GDF6
GDF9
HNRNPR
INHBB
LIMK1
LMX1A
LSM10
LSP1
MAP3K8
MAPK8
MERTK
MOS
NBEA
NOP56
PDZRN3
PMPCA
PPP1CC
PRKCB
RABGGTA
SMURF1
SULT1E1
TDGF1
TGFBR1
TOPBP1
TRIB3
TRPC1
TSR1
TUBB
TUBB4A
TWF1
Entrez ID
2661
659
HPRD ID
03560
02880
Ensembl ID
ENSG00000164404
ENSG00000204217
Uniprot IDs
B4DXG3
O60383
Q13873
PDB IDs
2HLQ
3G2F
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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