BMPR2 and BMP10

Data Source:
BioGRID (pull down)

		BMPR2	BMP10
Description		bone morphogenetic protein receptor type 2	bone morphogenetic protein 10
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Apical Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex Spanning Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc
	Molecular Function	Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding
	Biological Process	Blood Vessel Development Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Negative Regulation Of DNA Biosynthetic Process	Kidney Development Cell Adhesion Adult Heart Development Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Signaling by BMP	Signaling by BMP Molecules associated with elastic fibres
Drugs		Dibotermin alfa Fostamatinib
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) PR interval ( 32439900) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549 32154731) Urate levels ( 23263486)
Interacting Genes		52 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TDGF1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	59 interacting genes: ACVR2A ACVR2B APOA5 AQP6 ARL13B BIK BMPR2 BSCL2 BSND CCDC70 CD33 CISD2 CLDN7 COQ9 CREB3L1 DEXI EBP ERP29 FAM209A FCGR1A FCRL4 FFAR2 FKBP7 FNDC9 GGT6 GJB1 GPR152 GPX8 IL3RA JAGN1 KIR2DL3 KIR3DL1 KLRC1 LRRC25 LRRC4C MGST3 MRPS18B MS4A3 MTIF3 PLPP4 REEP4 SERINC3 SIT1 SLC10A1 SLC10A6 SLC35C2 SLC38A1 SLC4A1 SPAG4 TCTA TMEM14B TMEM31 TMEM45B TMEM86B TMPRSS2 TNFSF14 TNFSF8 TSPAN31 VSIR
Entrez ID		659	27302
HPRD ID		02880	09788
Ensembl ID		ENSG00000204217	ENSG00000163217
Uniprot IDs		Q13873	O95393
PDB IDs		2HLQ 3G2F	6SF1 6SF3
Enriched GO Terms of Interacting Partners?
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