BMPR2 and SULT1E1

Data Source:
HPRD (in vitro)

		BMPR2	SULT1E1
Description		bone morphogenetic protein receptor type 2	sulfotransferase family 1E member 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Apical Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex Spanning Component Of Plasma Membrane	Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Aryl Sulfotransferase Activity Estrone Sulfotransferase Activity Steroid Binding Protein Binding Sulfotransferase Activity Flavonol 3-sulfotransferase Activity Steroid Sulfotransferase Activity
	Biological Process	Blood Vessel Development Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Negative Regulation Of DNA Biosynthetic Process	Ethanol Catabolic Process Estrogen Catabolic Process Steroid Metabolic Process Estrogen Metabolic Process Positive Regulation Of Fat Cell Differentiation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		Signaling by BMP	Cytosolic sulfonation of small molecules
Drugs		Dibotermin alfa Fostamatinib	Cyclizine Adenosine 3',5'-diphosphate 3'-phospho-5'-adenylyl sulfate 3,3',5,5'-tetrachlorobiphenyl-4,4'-diol
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) PR interval ( 32439900) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549 32154731) Urate levels ( 23263486)	Heel bone mineral density ( 30598549)
Interacting Genes		52 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TDGF1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	13 interacting genes: BMPR2 COPS6 EEF1A1 ENOX1 ERG28 IGSF21 LRIF1 PDE9A RBM48 SETDB1 SULT2B1 TP53 UNC119
Entrez ID		659	6783
HPRD ID		02880	08966
Ensembl ID		ENSG00000204217	ENSG00000109193
Uniprot IDs		Q13873	P49888 Q53X91
PDB IDs		2HLQ 3G2F	1G3M 1HY3 4JVL 4JVM 4JVN
Enriched GO Terms of Interacting Partners?
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