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BMPR2 and MERTK
Data Source:
HPRD
(in vitro)
BMPR2
MERTK
Description
bone morphogenetic protein receptor type 2
MER proto-oncogene, tyrosine kinase
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleoplasm
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Adherens Junction
Basal Plasma Membrane
Cell Surface
Postsynaptic Density
Apical Plasma Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
Spanning Component Of Plasma Membrane
Photoreceptor Outer Segment
Extracellular Space
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Rhabdomere
Receptor Complex
Molecular Function
Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Protein Binding
ATP Binding
Activin Receptor Activity, Type II
Growth Factor Binding
BMP Binding
Cadherin Binding
Metal Ion Binding
BMP Receptor Activity
Protein Tyrosine Kinase Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Blood Vessel Development
Mesoderm Formation
Maternal Placenta Development
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lymphangiogenesis
Blood Vessel Remodeling
Chondrocyte Development
Negative Regulation Of Systemic Arterial Blood Pressure
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Development
Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Brain Development
Cellular Response To Starvation
Anterior/posterior Pattern Specification
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Lung Blood Pressure
Proteoglycan Biosynthetic Process
Negative Regulation Of Cell Growth
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Activin Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Vasoconstriction
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Cardiac Muscle Tissue Development
Positive Regulation Of Axon Extension Involved In Axon Guidance
Limb Development
Endochondral Bone Morphogenesis
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Positive Regulation Of Cartilage Development
Retina Vasculature Development In Camera-type Eye
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Endothelial Cell Apoptotic Process
Negative Regulation Of Chondrocyte Proliferation
Semi-lunar Valve Development
Negative Regulation Of DNA Biosynthetic Process
Natural Killer Cell Differentiation
Negative Regulation Of Cytokine Production
Protein Phosphorylation
Phagocytosis
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling
Multicellular Organism Development
Spermatogenesis
Nervous System Development
Cell Migration
Peptidyl-tyrosine Phosphorylation
Platelet Activation
Secretion By Cell
Positive Regulation Of Kinase Activity
Substrate Adhesion-dependent Cell Spreading
Protein Kinase B Signaling
Positive Regulation Of Phagocytosis
Leukocyte Migration
Negative Regulation Of Lymphocyte Activation
Retina Development In Camera-type Eye
Vagina Development
Neutrophil Clearance
Negative Regulation Of Leukocyte Apoptotic Process
Pathways
Signaling by BMP
Cell surface interactions at the vascular wall
Drugs
Dibotermin alfa
Fostamatinib
2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol
Fostamatinib
Diseases
Retinitis pigmentosa (RP)
GWAS
High light scatter reticulocyte percentage of red cells (
32888494
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
PR interval (
32439900
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32203549
32154731
)
Urate levels (
23263486
)
Acute anterior uveitis in ankylosing spondylitis (
32492107
)
Coronary artery disease (
29212778
33020668
)
Heel bone mineral density (
30598549
)
Hepatitis C induced liver fibrosis (
22841784
)
Multiple sclerosis (
31604244
21833088
)
Neutrophil percentage of white cells (
32888494
)
Systolic blood pressure (
30224653
)
Interacting Genes
52 interacting genes:
ACTR8
ACVR1
ACVR1B
ARSA
BMP10
BMP2
BMP4
BMP6
BMP7
BMPR1A
BMPR1B
C4BPA
CCDC89
CES1
CRYAB
CTBP1
DYNLT1
FHL2
FOXL1
FRS3
GDF2
GDF5
GDF6
GDF9
HNRNPR
INHBB
LIMK1
LMX1A
LSM10
LSP1
MAP3K8
MAPK8
MERTK
MOS
NBEA
NOP56
PDZRN3
PMPCA
PPP1CC
PRKCB
RABGGTA
SMURF1
SULT1E1
TDGF1
TGFBR1
TOPBP1
TRIB3
TRPC1
TSR1
TUBB
TUBB4A
TWF1
9 interacting genes:
BMPR2
ERBB2
GAS6
GRB2
IKBKG
LMO4
NEDD4L
TNK2
VAV1
Entrez ID
659
10461
HPRD ID
02880
05269
Ensembl ID
ENSG00000204217
ENSG00000153208
Uniprot IDs
Q13873
Q12866
PDB IDs
2HLQ
3G2F
2DBJ
2P0C
3BPR
3BRB
3TCP
4M3Q
4MH7
4MHA
5K0K
5K0X
5TC0
5TD2
5U6C
6MEP
7AAX
7AAY
7AAZ
7AB0
7AB1
7AB2
7CQE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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