RAB27A and SYTL4

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RAB27A	SYTL4
Description		RAB27A, member RAS oncogene family	synaptotagmin like 4
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Lysosome Late Endosome Golgi Apparatus Cytosol Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle	Endosome Plasma Membrane Extrinsic Component Of Membrane Transport Vesicle Membrane Platelet Alpha Granule Membrane Exocytic Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Protein Binding Phospholipid Binding Neurexin Family Protein Binding Metal Ion Binding
	Biological Process	Protein Targeting Exocytosis Blood Coagulation Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Plasma Membrane Repair Platelet Degranulation Intracellular Protein Transport Exocytosis Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair
Pathways		Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Platelet degranulation
Drugs			Insulin pork
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)	Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	27 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 ZBTB7B ZBTB9 ZRANB1
Entrez ID		5873	94121
HPRD ID		04845	06735
Ensembl ID		ENSG00000069974	ENSG00000102362
Uniprot IDs		A2RU94 P51159	A0A024RCF8 A8K973 B2R7R4 Q71SF7 Q96C24
PDB IDs		6HUF	2CSZ 3FDW 5X6T
Enriched GO Terms of Interacting Partners?
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