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RAB27A and RABGGTB
Data Source:
HPRD
(in vitro)
RAB27A
RABGGTB
Description
RAB27A, member RAS oncogene family
Rab geranylgeranyltransferase subunit beta
Image
GO Annotations
Cellular Component
Photoreceptor Outer Segment
Extracellular Region
Lysosome
Late Endosome
Golgi Apparatus
Cytosol
Apical Plasma Membrane
Secretory Granule
Dendrite
Secretory Granule Membrane
Multivesicular Body Membrane
Weibel-Palade Body
Melanosome Membrane
Specific Granule Lumen
Melanosome
Extracellular Exosome
Exocytic Vesicle
Cytosol
Plasma Membrane
Rab-protein Geranylgeranyltransferase Complex
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Domain Specific Binding
Myosin V Binding
Rab Geranylgeranyltransferase Activity
Protein Binding
Zinc Ion Binding
Small GTPase Binding
Biological Process
Protein Targeting
Exocytosis
Blood Coagulation
Positive Regulation Of Gene Expression
Antigen Processing And Presentation
Melanocyte Differentiation
Melanosome Localization
Melanosome Transport
Multivesicular Body Organization
Neutrophil Degranulation
Cytotoxic T Cell Degranulation
Natural Killer Cell Degranulation
Positive Regulation Of Exocytosis
Synaptic Vesicle Transport
Positive Regulation Of Phagocytosis
Multivesicular Body Sorting Pathway
Complement-dependent Cytotoxicity
Positive Regulation Of Regulated Secretory Pathway
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Positive Regulation Of Constitutive Secretory Pathway
Exosomal Secretion
Cellular Protein Modification Process
Visual Perception
Protein Phosphopantetheinylation
Protein Prenylation
Protein Geranylgeranylation
Regulation Of Apoptotic Process
Post-translational Protein Modification
Pathways
Insulin processing
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
RAB geranylgeranylation
Drugs
N-Formylmethionine
Farnesyl diphosphate
Geranylgeranyl diphosphate
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS
Fractional exhaled nitric oxide levels (
25431337
)
Glioma (
30714141
)
Daytime sleep phenotypes (
27126917
)
Serum metabolite levels (
23093944
)
Interacting Genes
28 interacting genes:
ADRB2
APP
CEP126
COPS6
EEF1A1
ERG28
EXPH5
GDF9
GDI1
GZMB
LRIF1
MLPH
MYO5A
MYRIP
RABGGTB
RBM48
RIMS1
RIMS2
RPH3A
RPH3AL
STX1A
SYTL1
SYTL2
SYTL3
SYTL4
SYTL5
UNC13D
ZBTB16
20 interacting genes:
ALAS2
ARAF
B4GALT7
CHML
IGFBP6
NPSR1
PTP4A2
RAB11A
RAB1A
RAB27A
RAB37
RAB3A
RAB5A
RAB6A
RAB7A
RABGGTA
SH3GLB1
TAFA1
TMEM25
WDR4
Entrez ID
5873
5876
HPRD ID
04845
01532
Ensembl ID
ENSG00000069974
ENSG00000137955
Uniprot IDs
A2RU94
P51159
A8KAJ2
P53611
Q6IB63
PDB IDs
6HUF
6J6X
6J74
6J7F
6J7X
6O60
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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