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KAT2A and TSC1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
KAT2A
TSC1
Description
lysine acetyltransferase 2A
TSC complex subunit 1
Image
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
Extracellular Space
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Chromosome
Centrosome
STAGA Complex
Transcription Factor TFTC Complex
Oxoglutarate Dehydrogenase Complex
Mitotic Spindle
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Molecular Function
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Transcription Factor Binding
H3 Histone Acetyltransferase Activity
Protein Phosphatase Binding
Histone Deacetylase Binding
Histone Acetyltransferase Activity (H4-K12 Specific)
Peptide-lysine-N-acetyltransferase Activity
Histone Succinyltransferase Activity
Histone Glutaryltransferase Activity
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
Biological Process
In Utero Embryonic Development
Somitogenesis
Cytokine Production
Neural Tube Closure
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Heart Development
Long-term Memory
Cell Population Proliferation
Response To Organic Cyclic Compound
Viral Process
Histone Acetylation
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Telencephalon Development
Metencephalon Development
Midbrain Development
Positive Regulation Of Cell Projection Organization
Regulation Of Protein Stability
Response To Nutrient Levels
Positive Regulation Of Histone Acetylation
Multicellular Organism Growth
Histone H3 Acetylation
Histone H4-K12 Acetylation
Histone H3-K14 Acetylation
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Regulation Of Synaptic Plasticity
Intracellular Distribution Of Mitochondria
Regulation Of T Cell Activation
Limb Development
Regulation Of Cartilage Development
Cellular Response To Tumor Necrosis Factor
Alpha-tubulin Acetylation
Histone Succinylation
Peptidyl-lysine Glutarylation
Regulation Of Bone Development
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Cardiac Muscle Cell Differentiation
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Ub-specific processing proteases
RNA Polymerase I Transcription Initiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Coenzyme A
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Coronary artery disease (
29212778
33020668
)
Inflammatory bowel disease (
26278503
)
Mean reticulocyte volume (
32888494
)
Vitiligo (
27723757
)
vWF and FVIII levels (
30586737
)
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Interacting Genes
60 interacting genes:
AKT1
ATXN7
BATF2
BECN1
CCND2
CCNE1
CDK2
CDK6
CDKN2B
CEBPB
COMMD1
CREBBP
CRX
CTNNB1
CUL2
DTL
EID1
EP300
FZR1
GATA2
GRM1
H1-5
H2AC20
H2BC21
H3-4
H3C14
H4-16
H4C14
HSD11B2
IRF1
IRF2
IRF7
KDELR2
LATS2
MAP2K3
MAPK14
MYB
MYC
NF2
NOTCH1
PBX1
PPARG
PRKDC
PYGO2
RASSF1
RBPJ
RELA
SIRT2
STK11
TACC1
TACC2
TACC3
TADA2A
TCF3
TP53
TRRAP
TSC1
TTYH2
UBE2I
XRCC6
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
Entrez ID
2648
7248
HPRD ID
03807
05594
Ensembl ID
ENSG00000108773
ENSG00000165699
Uniprot IDs
Q92830
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
PDB IDs
1F68
1Z4R
3D7C
5H84
5H86
5MLJ
5TRL
5TRM
6J3P
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
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