APLF and XRCC4

Data Source:
HPRD (in vitro)

		APLF	XRCC4
Description		aprataxin and PNKP like factor	X-ray repair cross complementing 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break	Condensed Chromosome Nucleus Nucleoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity Identical Protein Binding
	Biological Process	Single Strand Break Repair Double-strand Break Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency Protein Localization To Site Of Double-strand Break
Pathways			2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)
Drugs			S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)	Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4	23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 PNKP PRKDC VIM
Entrez ID		200558	7518
HPRD ID		09848	15951
Ensembl ID		ENSG00000169621	ENSG00000152422
Uniprot IDs		Q8IW19	A0A024RAL0 A0A024RAP0 A0A024RAQ8 Q13426 Q7Z763
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ	1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?