APLF and FBXO25

Data Source:
BioGRID (enzymatic study)

		APLF	FBXO25
Description		aprataxin and PNKP like factor	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Single Strand Break Repair Double-strand Break Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		200558	26260
HPRD ID		09848	16439
Ensembl ID		ENSG00000169621	ENSG00000147364
Uniprot IDs		Q8IW19	A0A024QZ88 Q8TCJ0
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ
Enriched GO Terms of Interacting Partners?
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