PTPRB and NRCAM

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		PTPRB	NRCAM
Description		protein tyrosine phosphatase receptor type B	neuronal cell adhesion molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuron Projection Axon Initial Segment
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Cadherin Binding	Protein Binding Ankyrin Binding
	Biological Process	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Neutrophil Degranulation Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Angiogenesis Neuron Migration Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Regulation Of Axon Extension Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation Cell-cell Adhesion
Pathways		Neutrophil degranulation	Interaction between L1 and Ankyrins NrCAM interactions Neurofascin interactions
Drugs		{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)	Blood protein levels ( 30072576) Coffee consumption ( 21876539) Diastolic blood pressure ( 27841878) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333) White matter hyperintensity burden ( 25663218)
Interacting Genes		11 interacting genes: CDH5 CNTN1 CNTNAP1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC	8 interacting genes: ANK2 CNTN2 HSPA12A LNX1 MACF1 MAGI3 NFASC PTPRB
Entrez ID		5787	4897
HPRD ID		01474	07207
Ensembl ID		ENSG00000127329	ENSG00000091129
Uniprot IDs		F8VU56 P23467 Q68D73 Q86VA4	B7Z670 C9JYY6 Q14CA1 Q92823
PDB IDs		2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X	1UEN 1UEY
Enriched GO Terms of Interacting Partners?
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