PTPRB and CNTNAP1

Data Source:
HPRD (in vivo)

		PTPRB	CNTNAP1
Description		protein tyrosine phosphatase receptor type B	contactin associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane	Integral Component Of Plasma Membrane Integral Component Of Membrane Paranodal Junction Paranode Region Of Axon Presynaptic Active Zone Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Cadherin Binding	Protein Binding SH3 Domain Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Neutrophil Degranulation Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Protein Localization To Paranode Region Of Axon Cytoskeleton Organization Cell Adhesion Signal Transduction Neuronal Action Potential Propagation Central Nervous System Myelination Myelination In Peripheral Nervous System Paranodal Junction Assembly Neuron Projection Morphogenesis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Protein Localization To Juxtaparanode Region Of Axon
Pathways		Neutrophil degranulation	Neurofascin interactions
Drugs		{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)	Breast cancer ( 29059683) Major depressive disorder ( 27777418)
Interacting Genes		11 interacting genes: CDH5 CNTN1 CNTNAP1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC	7 interacting genes: CCR4 FYN NFASC PTPRB RHOA RTN4 SRC
Entrez ID		5787	8506
HPRD ID		01474	03825
Ensembl ID		ENSG00000127329	ENSG00000108797
Uniprot IDs		F8VU56 P23467 Q68D73 Q86VA4	P78357
PDB IDs		2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X
Enriched GO Terms of Interacting Partners?
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