PTPRB and CNTN1

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		PTPRB	CNTN1
Description		protein tyrosine phosphatase receptor type B	contactin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane	Membrane Membrane Raft Extracellular Exosome Anchored Component Of Postsynaptic Membrane Anchored Component Of Presynaptic Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Cadherin Binding	Protein Binding Carbohydrate Binding
	Biological Process	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Neutrophil Degranulation Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Cell Adhesion Notch Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		Neutrophil degranulation	Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions
Drugs		{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)
Interacting Genes		11 interacting genes: CDH5 CNTN1 CNTNAP1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC	14 interacting genes: CNTN2 FYN GPR37 L1CAM MAPK6 NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TNC TNR
Entrez ID		5787	1272
HPRD ID		01474	07189
Ensembl ID		ENSG00000127329	ENSG00000018236
Uniprot IDs		F8VU56 P23467 Q68D73 Q86VA4	A0A024R104 Q12860
PDB IDs		2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X	2EE2 3S97
Enriched GO Terms of Interacting Partners?
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