NGEF and FAM118B

Data Source:
BioGRID (two hybrid)

		NGEF	FAM118B
Description		neuronal guanine nucleotide exchange factor	family with sequence similarity 118 member B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Growth Cone	Cajal Body
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Nervous System Development Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Activation Of GTPase Activity	Cajal Body Organization
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 30598549 28869591) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		14 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63	29 interacting genes: BAG5 CEP126 CEP70 CTSB FAM118A FAM20C GNB2 ING5 ITFG1 MCM3AP MED31 NGEF PDCD10 PIAS2 QARS1 RAD54L2 RASGRP2 RBM48 SDCBP SEMA5B SETDB1 SHC1 SPRED1 SUMO1 SUMO1P1 TMSB4X VIM ZNF235 ZNF746
Entrez ID		25791	79607
HPRD ID		10442	07952
Ensembl ID		ENSG00000066248	ENSG00000197798
Uniprot IDs		B4DDI2 Q8N5V2	A0A024R3L8 J3KP39 Q9BPY3
PDB IDs
Enriched GO Terms of Interacting Partners?
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