NGEF and MRPL44

Data Source:
BioGRID (two hybrid)

		NGEF	MRPL44
Description		neuronal guanine nucleotide exchange factor	mitochondrial ribosomal protein L44
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Growth Cone	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Plasma Membrane Nuclear Body
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	RNA Binding Double-stranded RNA Binding Ribonuclease III Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Nervous System Development Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Activation Of GTPase Activity	RNA Processing Production Of SiRNA Involved In RNA Interference Primary MiRNA Processing Pre-miRNA Processing Mitochondrial Translational Elongation Mitochondrial Translational Termination RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 30598549 28869591) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		14 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63	15 interacting genes: ABI2 CEP70 DGKE IMMT ITFG1 NGEF PI4KA PLPP2 PTN SEMA5B SETDB1 SHC1 USP22 VIM ZNF235
Entrez ID		25791	65080
HPRD ID		10442	14763
Ensembl ID		ENSG00000066248	ENSG00000135900
Uniprot IDs		B4DDI2 Q8N5V2	A1MA90 Q9H9J2
PDB IDs			3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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