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NGEF and EPHA4
Data Source:
HPRD
(in vivo, two hybrid)
NGEF
EPHA4
Description
neuronal guanine nucleotide exchange factor
EPH receptor A4
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Membrane
Growth Cone
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Adherens Junction
Cell Surface
Filopodium
Axon
Dendrite
Neuromuscular Junction
Early Endosome Membrane
Neuron Projection
Dendritic Spine
Dendritic Shaft
Perikaryon
Receptor Complex
Axon Terminus
Axonal Growth Cone
Schaffer Collateral - CA1 Synapse
Postsynaptic Density Membrane
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Amyloid-beta Binding
Protein Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Transmembrane-ephrin Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
PH Domain Binding
Identical Protein Binding
Ephrin Receptor Binding
DH Domain Binding
Protein Tyrosine Kinase Binding
Biological Process
G Protein-coupled Receptor Signaling Pathway
Nervous System Development
Cell Differentiation
Positive Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Ephrin Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Negative Regulation Of Dendritic Spine Morphogenesis
Activation Of GTPase Activity
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Adult Walking Behavior
Motor Neuron Axon Guidance
Glial Cell Migration
Negative Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Corticospinal Tract Morphogenesis
Positive Regulation Of Kinase Activity
Adherens Junction Organization
Regulation Of GTPase Activity
Positive Regulation Of JUN Kinase Activity
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Negative Regulation Of Axon Regeneration
Regulation Of Astrocyte Differentiation
Regulation Of Axonogenesis
Positive Regulation Of Dendrite Morphogenesis
Protein Stabilization
Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Protein Tyrosine Kinase Activity
Nephric Duct Morphogenesis
Cochlea Development
Fasciculation Of Sensory Neuron Axon
Fasciculation Of Motor Neuron Axon
Neuron Projection Guidance
Synapse Pruning
Neuron Projection Fasciculation
Negative Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Response To Amyloid-beta
Regulation Of Modification Of Synaptic Structure
Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways
NRAGE signals death through JNK
Rho GTPase cycle
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
Drugs
Fostamatinib
Diseases
GWAS
anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Contrast sensitivity (
24152035
)
Heel bone mineral density (
30598549
28869591
)
Parkinson's disease (
32201043
)
Pursuit maintenance gain (
29064472
)
Schizophrenia (
28991256
25056061
29483656
30285260
23974872
)
Sudden cardiac arrest (
30169657
)
Superior temporal sulcus banks volume (
31530798
)
Adolescent idiopathic scoliosis (
26394188
)
Blond vs. brown/black hair color (
30531825
)
Brain imaging (
20100581
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Brown vs. black hair color (
30531825
)
Cortical surface area (MOSTest) (
32665545
)
Diffusing capacity of carbon monoxide (
30694715
)
Diisocyanate-induced asthma (
25918132
)
Entorhinal cortical volume (
31530798
)
Face memory (
31596458
)
Hair color (
29662168
)
Heel bone mineral density (
30598549
)
Immune response to measles-mumps-rubella vaccine (
24811271
)
Nose size (
27182965
)
Paclitaxel-induced neuropathy (
23776197
)
Rostral anterior cingulate cortex volume (
31530798
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Urate levels in lean individuals (
25811787
)
Interacting Genes
14 interacting genes:
ATP5F1C
C7orf25
C8orf33
EPHA4
FAM118B
HCK
MRPL44
NUDT21
RHOA
SH2D1A
SMO
TAF1D
TRIM55
TRIM63
17 interacting genes:
ARHGEF15
EFNA1
EFNA3
EFNA4
EFNA5
EFNB2
EFNB3
ERBB2
FGFR1
FGFR2
FGFR3
FGFR4
FYN
IKBKG
NGEF
SRC
TNS3
Entrez ID
25791
2043
HPRD ID
10442
03719
Ensembl ID
ENSG00000066248
ENSG00000116106
Uniprot IDs
B4DDI2
Q8N5V2
A1MA61
P54764
PDB IDs
2LW8
2WO1
2WO2
2WO3
3CKH
3GXU
4BK4
4BK5
4BKA
4BKF
4M4P
4M4R
4W4Z
4W50
5JR2
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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