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NGEF and SMO
Data Source:
BioGRID
(two hybrid)
NGEF
SMO
Description
neuronal guanine nucleotide exchange factor
smoothened, frizzled class receptor
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Membrane
Growth Cone
Golgi Apparatus
Plasma Membrane
Caveola
Cilium
Integral Component Of Membrane
Dendrite
Endocytic Vesicle Membrane
Intracellular Membrane-bounded Organelle
Ciliary Membrane
Extracellular Exosome
Ciliary Tip
9+0 Non-motile Cilium
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
G Protein-coupled Receptor Activity
Patched Binding
Protein Binding
Biological Process
G Protein-coupled Receptor Signaling Pathway
Nervous System Development
Cell Differentiation
Positive Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Ephrin Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Negative Regulation Of Dendritic Spine Morphogenesis
Activation Of GTPase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Osteoblast Differentiation
In Utero Embryonic Development
Cell Fate Specification
Neural Crest Cell Migration
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Determination Of Left/right Asymmetry In Lateral Mesoderm
Type B Pancreatic Cell Development
G Protein-coupled Receptor Signaling Pathway
Smoothened Signaling Pathway
Positive Regulation Of Hh Target Transcription Factor Activity
Ventral Midline Determination
Central Nervous System Development
Midgut Development
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dentate Gyrus Development
Cerebellar Cortex Morphogenesis
Thalamus Development
Dorsal/ventral Neural Tube Patterning
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Central Nervous System Neuron Differentiation
Cerebral Cortex Development
Positive Regulation Of Cell Migration
Negative Regulation Of Epithelial Cell Differentiation
Hair Follicle Morphogenesis
Protein Localization To Nucleus
Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Protein Import Into Nucleus
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Positive Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Organ Growth
Astrocyte Activation
Skeletal Muscle Fiber Development
Smooth Muscle Tissue Development
Forebrain Morphogenesis
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Epithelial Cell Proliferation
Protein Stabilization
Myoblast Migration
Negative Regulation Of Hair Follicle Development
Contact Inhibition
Atrial Septum Morphogenesis
Mammary Gland Epithelial Cell Differentiation
Epithelial-mesenchymal Cell Signaling
Somite Development
Pancreas Morphogenesis
Left/right Axis Specification
Cellular Response To Cholesterol
Commissural Neuron Axon Guidance
Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Stem Cell Population Maintenance
Regulation Of Heart Morphogenesis
Pathways
NRAGE signals death through JNK
Rho GTPase cycle
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Class B/2 (Secretin family receptors)
Hedgehog 'off' state
BBSome-mediated cargo-targeting to cilium
Hedgehog 'on' state
Activation of SMO
Activation of SMO
Drugs
Fluocinonide
Halcinonide
Vismodegib
Sonidegib
Glasdegib
Diseases
Basal cell carcinoma
GWAS
anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Contrast sensitivity (
24152035
)
Heel bone mineral density (
30598549
28869591
)
Parkinson's disease (
32201043
)
Pursuit maintenance gain (
29064472
)
Schizophrenia (
28991256
25056061
29483656
30285260
23974872
)
Sudden cardiac arrest (
30169657
)
Superior temporal sulcus banks volume (
31530798
)
Osteoarthritis (hip) (
30374069
)
Interacting Genes
14 interacting genes:
ATP5F1C
C7orf25
C8orf33
EPHA4
FAM118B
HCK
MRPL44
NUDT21
RHOA
SH2D1A
SMO
TAF1D
TRIM55
TRIM63
28 interacting genes:
ARV1
C18orf32
C4orf3
EMC10
FKBP8
GABARAPL2
GABBR1
HMGN4
HMOX1
HMOX2
ITGB1BP1
JPH3
LEPROT
NDFIP1
NEDD4
NGEF
NIPA1
PLPP7
PTCH1
PTCH2
RPN2
S1PR5
SLC41A3
SSPN
TIMMDC1
TMCC2
TSPAN7
WLS
Entrez ID
25791
6608
HPRD ID
10442
03294
Ensembl ID
ENSG00000066248
ENSG00000128602
Uniprot IDs
B4DDI2
Q8N5V2
Q99835
PDB IDs
4JKV
4N4W
4O9R
4QIM
4QIN
5L7D
5L7I
5V56
5V57
6OT0
6XBJ
6XBK
6XBL
6XBM
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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