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FAM118B and SPRED1
Data Source:
BioGRID
(two hybrid)
FAM118B
SPRED1
Description
family with sequence similarity 118 member B
sprouty related EVH1 domain containing 1
Image
No pdb structure
GO Annotations
Cellular Component
Cajal Body
Nucleoplasm
Cytosol
Plasma Membrane
Caveola
Cytoplasmic Vesicle
Molecular Function
Protein Binding
Identical Protein Binding
Stem Cell Factor Receptor Binding
Protein Binding
Protein Kinase Binding
Phosphatase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Biological Process
Cajal Body Organization
MAPK Cascade
Inactivation Of MAPK Activity
Negative Regulation Of Protein Kinase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Phosphatase Activity
Negative Regulation Of Angiogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of MAPK Cascade
Negative Regulation Of MAPK Cascade
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Vasculogenesis Involved In Coronary Vascular Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Protein Deacetylation
Negative Regulation Of Lens Fiber Cell Differentiation
Pathways
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling
RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Bipolar disorder (
20351715
)
Birth weight (
31043758
)
Cognitive performance (processing speed) (
31598132
)
Crohn's disease (
23128233
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Erosive tooth wear (severe vs none or mild) (
29898447
)
HDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
Hypersomnia (HLA-DQB1*06:02 negative) (
23646285
)
Interacting Genes
29 interacting genes:
BAG5
CEP126
CEP70
CTSB
FAM118A
FAM20C
GNB2
ING5
ITFG1
MCM3AP
MED31
NGEF
PDCD10
PIAS2
QARS1
RAD54L2
RASGRP2
RBM48
SDCBP
SEMA5B
SETDB1
SHC1
SPRED1
SUMO1
SUMO1P1
TMSB4X
VIM
ZNF235
ZNF746
37 interacting genes:
ANKS1A
AQP1
BEX2
BLZF1
C2orf68
CCDC185
CDKN1A
CREB5
DNAJB11
FAM118B
FAM90A1
GLYCTK
HEXIM2
HPCAL4
HSF2BP
IL16
KIT
MAB21L3
MEOX2
NAGK
NCALD
OSGEP
PIH1D2
PPP1CA
PPP1R7
PRPF18
RCC1
RIN1
SPG21
SUV39H1
TSC22D1
TTC19
VSNL1
ZNF408
ZNF417
ZNF587
ZNF655
Entrez ID
79607
161742
HPRD ID
07952
11601
Ensembl ID
ENSG00000197798
ENSG00000166068
Uniprot IDs
A0A024R3L8
J3KP39
Q9BPY3
Q7Z699
PDB IDs
3SYX
6V65
6V6F
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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