JMJD6 and PRPF38A

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		JMJD6	PRPF38A
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	pre-mRNA processing factor 38A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Nucleus Nucleoplasm U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity	RNA Binding Protein Binding
	Biological Process	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation	MRNA Splicing, Via Spliceosome
Pathways		HDMs demethylate histones	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	24 interacting genes: AP2M1 APP CHERP CLK1 CLK2 CSNK2A1 DHX8 DVL3 GTF3C1 JMJD6 MAPK6 POLA2 PPIG PRMT5 RBM39 RNPS1 SDCBP SDCBP2 SRPK1 SRPK2 SRSF4 SRSF7 U2AF1 ZCCHC10
Entrez ID		23210	84950
HPRD ID		05371	10972
Ensembl ID		ENSG00000070495	ENSG00000134748
Uniprot IDs		Q6NYC1	Q8NAV1
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	4RZ9 4RZA 5F5S 5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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