JMJD6 and NHP2

Data Source:
BioGRID (two hybrid)

		JMJD6	NHP2
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	NHP2 ribonucleoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Chromosome, Telomeric Region Nucleoplasm Telomerase Holoenzyme Complex Sno(s)RNA-containing Ribonucleoprotein Complex Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity	RNA Binding Protein Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation	Cleavage Involved In RRNA Processing Maturation Of LSU-rRNA Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		HDMs demethylate histones	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases			Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)	Platelet count ( 29403010)
Interacting Genes		27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	9 interacting genes: IKBKG JMJD6 MYL2 NEDD4 NEDD4L NOP10 NOS1AP PRNP UTP23
Entrez ID		23210	55651
HPRD ID		05371	07570
Ensembl ID		ENSG00000070495	ENSG00000145912
Uniprot IDs		Q6NYC1	J3QSY4 Q9NX24
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?
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