JMJD6 and STAC3

Data Source:
BioGRID (two hybrid)

		JMJD6	STAC3
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	SH3 and cysteine rich domain 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Nucleoplasm Cytosol Voltage-gated Calcium Channel Complex T-tubule Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Synapse
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity	Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation	Skeletal Muscle Contraction Neuromuscular Synaptic Transmission Intracellular Signal Transduction Skeletal Muscle Fiber Development Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		HDMs demethylate histones
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 25056061 29483656)
Interacting Genes		27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	38 interacting genes: ANKRD36 BAZ2B C1orf35 CSNK2A1 DIP2A EAF1 EAF2 ENKD1 FAM124A FAM133A FAM90A1 FAM9A FGF11 FGF12 GAS8 GIGYF1 GRB7 HMGXB4 INO80B JMJD6 L3MBTL2 MAB21L3 MFAP1 NKAPD1 NSD3 PPARA RPL22 RPL9 RPS25 SPANXN2 SPANXN3 SREK1IP1 TCEA2 TNFAIP8L1 U2AF2 VCX2 ZCCHC10 ZGPAT
Entrez ID		23210	246329
HPRD ID		05371	11606
Ensembl ID		ENSG00000070495	ENSG00000185482
Uniprot IDs		Q6NYC1	A0A024RB38 Q96MF2
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	2DB6 6B29 6UY7 6UY8 6UY9
Enriched GO Terms of Interacting Partners?
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