PRPF38A and POLA2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRPF38A	POLA2
Description		pre-mRNA processing factor 38A	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	RNA Binding Protein Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways		mRNA Splicing - Major Pathway	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS			Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		24 interacting genes: AP2M1 APP CHERP CLK1 CLK2 CSNK2A1 DHX8 DVL3 GTF3C1 JMJD6 MAPK6 POLA2 PPIG PRMT5 RBM39 RNPS1 SDCBP SDCBP2 SRPK1 SRPK2 SRSF4 SRSF7 U2AF1 ZCCHC10	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		84950	23649
HPRD ID		10972	10160
Ensembl ID		ENSG00000134748	ENSG00000014138
Uniprot IDs		Q8NAV1	Q14181
PDB IDs		4RZ9 4RZA 5F5S 5O9Z 6AHD	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?