JMJD6 and CXCL14

Data Source:
BioGRID (pull down)

		JMJD6	CXCL14
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	C-X-C motif chemokine ligand 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Extracellular Space Golgi Apparatus
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity	Protein Binding Chemokine Activity
	Biological Process	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation	Chemotaxis Signal Transduction Cell-cell Signaling Negative Regulation Of Myoblast Differentiation Inner Ear Development Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		HDMs demethylate histones
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321)
Interacting Genes		27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	28 interacting genes: APP CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL17 CXCL2 CXCL5 CXCL9 F2R GPR85 JMJD6 KLRC1 LMNA PF4 PPBP REL ROBO3 SLAMF6 TEX11 TNFRSF10C TRIM23 XCL1
Entrez ID		23210	9547
HPRD ID		05371	16049
Ensembl ID		ENSG00000070495	ENSG00000145824
Uniprot IDs		Q6NYC1	O95715
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	2HDL
Enriched GO Terms of Interacting Partners?
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