JMJD6 and CENPL

Data Source:
BioGRID (two hybrid)

		JMJD6	CENPL
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	centromere protein L
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Chromosome, Centromeric Region Nucleoplasm Cytosol
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity	Protein Binding
	Biological Process	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation	CENP-A Containing Nucleosome Assembly
Pathways		HDMs demethylate histones	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	2 interacting genes: FAM9B JMJD6
Entrez ID		23210	91687
HPRD ID		05371	15909
Ensembl ID		ENSG00000070495	ENSG00000120334
Uniprot IDs		Q6NYC1	A0A024R8Z8 Q8N0S6
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?
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