JMJD6 and H2BC11

Data Source:
BioGRID (two hybrid)

		JMJD6	H2BC11
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	H2B clustered histone 11
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity	Lipopolysaccharide Binding DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation	Innate Immune Response In Mucosa Nucleosome Assembly Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Antibacterial Humoral Response Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		HDMs demethylate histones	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	4 interacting genes: JMJD6 LOX SPANXN2 TLX3
Entrez ID		23210	8970
HPRD ID		05371	13657
Ensembl ID		ENSG00000070495	ENSG00000124635
Uniprot IDs		Q6NYC1	A0A024RCJ2 P06899
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WA9 3WAA 3WTP 4CAY 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5CPI 5CPJ 5CPK 5FUG 5GSE 5GTC 5GXQ 5JRG 5VEY 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5Z30 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IPU 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JOU 6JR0 6JR1 6JXD 6K1I 6K1J 6K1K 6KVD 6KXV 6L49 6L4A 6LA8 6LA9 6M3V 6M44 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T90 6T93 6USJ 6YOV 7C0M 7CCQ 7CCR
Enriched GO Terms of Interacting Partners?
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