SPEN and UBE2L6

Data Source:
HPRD (in vitro, two hybrid)

		SPEN	UBE2L6
Description		spen family transcriptional repressor	ubiquitin conjugating enzyme E2 L6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Factor Binding Nucleic Acid Binding DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Phosphopantetheinylation Translesion Synthesis ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591) Hemoglobin levels ( 32327693)	Blood protein levels ( 28240269)
Interacting Genes		22 interacting genes: ATXN1 CLK1 CTBP1 DLX5 HDAC1 HDAC2 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6	40 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MID1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A
Entrez ID		23013	9246
HPRD ID		10230	04867
Ensembl ID		ENSG00000065526	ENSG00000156587
Uniprot IDs		Q96T58	O14933
PDB IDs		1OW1 2RT5 4P6Q	1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?
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