UBE2L6 and SIAH2

Data Source:
HPRD (in vivo)

		UBE2L6	SIAH2
Description		ubiquitin conjugating enzyme E2 L6	siah E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Phosphopantetheinylation Translesion Synthesis ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Small GTPase Mediated Signal Transduction Multicellular Organism Development Protein Deubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Netrin-activated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)
Interacting Genes		40 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MID1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A	43 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCBE1 CHEK2 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1
Entrez ID		9246	6478
HPRD ID		04867	03737
Ensembl ID		ENSG00000156587	ENSG00000181788
Uniprot IDs		O14933	O43255
PDB IDs		1WZV 1WZW 2KJH	5H9M
Enriched GO Terms of Interacting Partners?
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