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SPEN and RARA
Data Source:
HPRD
(in vivo)
SPEN
RARA
Description
spen family transcriptional repressor
retinoic acid receptor alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Repressor Complex
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell Surface
Actin Cytoskeleton
Protein-containing Complex
Molecular Function
RNA Polymerase II Transcription Factor Binding
Nucleic Acid Binding
DNA Binding
Transcription Corepressor Activity
RNA Binding
Protein Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein Kinase B Binding
Retinoic Acid-responsive Element Binding
Protein Kinase A Binding
Alpha-actinin Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Splicing, Via Spliceosome
Notch Signaling Pathway
Viral Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Neurogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Hormone-mediated Signaling Pathway
Cell Differentiation
Negative Regulation Of Granulocyte Differentiation
Response To Retinoic Acid
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Apoptotic Cell Clearance
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Binding
Cellular Response To Estrogen Stimulus
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Drugs
Adapalene
Acitretin
Alitretinoin
Tretinoin
Tazarotene
Etretinate
Isotretinoin
Tamibarotene
LGD-1550
Trifarotene
Diseases
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
Acute myeloid leukemia (AML)
GWAS
Erectile dysfunction (
30583798
)
Heel bone mineral density (
28869591
)
Hemoglobin levels (
32327693
)
Asthma (
31619474
)
Interacting Genes
22 interacting genes:
ATXN1
CLK1
CTBP1
DLX5
HDAC1
HDAC2
MBD3
MSX2
MTA2
NCOR1
NCOR2
PPARD
RARA
RBBP4
RBPJ
RIDA
RUNX1
RUNX1T1
SERTAD1
SOX9
SRPK2
UBE2L6
97 interacting genes:
ACTN4
AKT1
ALOX15B
ALX1
ARID1A
ARID5A
ARNTL
BAG1
BBS4
BTG1
CCND3
CCNDBP1
CDK7
CEBPA
CLOCK
CNOT1
COPS2
E2F1
ESR1
FGFR1
FN1
FOXO1
GADD45G
GATA2
HDAC1
HDAC3
HDAC4
HMGA1
HR
IRX4
ITGB1BP2
KAT2B
KDM5A
KLF5
LRIF1
MAPK6
MCRS1
MDM2
MECR
MED1
MED25
MED6
MMS19
NCOA1
NCOA2
NCOA3
NCOA6
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR2C1
NR2E3
NR3C1
NRBF2
NRIP1
NRIP2
NSD1
PARP1
PHF8
PIN1
PLEKHF2
PML
PNRC2
POU2F1
PPARG
PRAME
PRDX6
PRKCA
PSMC5
RXRA
RXRB
RXRG
S100A3
SIRT1
SMARCD3
SNW1
SP1
SPEN
SRC
SRF
STAT5B
TADA3
TEKT4
THRB
TNIP1
TOP2B
TRIB3
TRIM24
TRIP4
UBE3A
UBQLN1
USP7
ZBTB16
Entrez ID
23013
5914
HPRD ID
10230
06769
Ensembl ID
ENSG00000065526
ENSG00000131759
Uniprot IDs
Q96T58
A8K840
A8MUP8
F1D8N9
P10276
Q6I9R7
PDB IDs
1OW1
2RT5
4P6Q
1DKF
1DSZ
3A9E
3KMR
3KMZ
4DQM
5K13
6XWG
Enriched GO Terms of Interacting Partners
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