Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
SPEN and NCOR1
Data Source:
HPRD
(two hybrid)
SPEN
NCOR1
Description
spen family transcriptional repressor
nuclear receptor corepressor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Repressor Complex
Extracellular Exosome
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Membrane
Sin3 Complex
Transcription Repressor Complex
Mitotic Spindle
Molecular Function
RNA Polymerase II Transcription Factor Binding
Nucleic Acid Binding
DNA Binding
Transcription Corepressor Activity
RNA Binding
Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
Transcription Corepressor Activity
Protein Binding
Nuclear Hormone Receptor Binding
Histone Deacetylase Binding
Thyroid Hormone Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Splicing, Via Spliceosome
Notch Signaling Pathway
Viral Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Neurogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Circadian Rhythm
Regulation Of Lipid Metabolic Process
Locomotor Rhythm
Negative Regulation Of Glycolytic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Fatty Acid Metabolic Process
Negative Regulation Of JNK Cascade
Spindle Assembly
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Diseases
GWAS
Erectile dysfunction (
30583798
)
Heel bone mineral density (
28869591
)
Hemoglobin levels (
32327693
)
Adult body size (
32376654
)
C-reactive protein levels (
30388399
)
FEV1 (
30804560
)
Free thyroxine concentration (
30367059
)
Lung function (FEV1) (
26635082
)
Lung function (FVC) (
30804560
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Interacting Genes
22 interacting genes:
ATXN1
CLK1
CTBP1
DLX5
HDAC1
HDAC2
MBD3
MSX2
MTA2
NCOR1
NCOR2
PPARD
RARA
RBBP4
RBPJ
RIDA
RUNX1
RUNX1T1
SERTAD1
SOX9
SRPK2
UBE2L6
89 interacting genes:
ACTN2
AR
ATXN1
ATXN1L
ATXN3
BCL6
C1D
CBFA2T2
CHD1
CHUK
CLK1
CNOT2
COPS2
CSNK2A1
CXADR
DACH1
DDX20
DHX30
DZIP3
ENO1
ESR1
ESR2
ETS1
ETS2
GPS2
GTF2B
H3C1
H4C1
HDAC3
HDAC5
HDAC9
HESX1
HEY2
HTT
KLF5
MECP2
MYB
MYBL2
MYOD1
NCOA1
NCOA3
NCOR2
NELFE
NR1D1
NR1D2
NR1H2
NR1H3
NR2E3
NR3C1
NR6A1
PDCD2
PHB
PIAS1
PML
POU1F1
PPARA
PPARD
PPARG
PTMA
RARA
RARG
RBPJ
RUNX1
RUNX1T1
RXRA
SAFB
SAP30
SKI
SKIL
SNW1
SP1
SPEN
SQSTM1
SUMO2
TAB2
TAF6
TAF9
TBL1X
TBL1XR1
THRA
THRB
TRIM14
TULP3
TXNRD2
VDR
ZBTB16
ZBTB33
ZBTB7A
ZMYND11
Entrez ID
23013
9611
HPRD ID
10230
02911
Ensembl ID
ENSG00000065526
ENSG00000141027
Uniprot IDs
Q96T58
A0A024RD47
O75376
Q6PGR4
PDB IDs
1OW1
2RT5
4P6Q
2EQR
3H52
3KMZ
3N00
4MDD
4WVD
6ONI
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?