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SPEN and DLX5
Data Source:
HPRD
(in vitro)
SPEN
DLX5
Description
spen family transcriptional repressor
distal-less homeobox 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Repressor Complex
Extracellular Exosome
Chromatin
Nucleus
Cytoplasm
Molecular Function
RNA Polymerase II Transcription Factor Binding
Nucleic Acid Binding
DNA Binding
Transcription Corepressor Activity
RNA Binding
Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
HMG Box Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Splicing, Via Spliceosome
Notch Signaling Pathway
Viral Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Neurogenesis
Skeletal System Development
Osteoblast Differentiation
Endochondral Ossification
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
Cell Population Proliferation
Embryo Development
Olfactory Bulb Interneuron Differentiation
Cell Differentiation
Embryonic Limb Morphogenesis
BMP Signaling Pathway
Epithelial Cell Differentiation
Inner Ear Morphogenesis
Positive Regulation Of Transcription, DNA-templated
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Roof Of Mouth Development
Olfactory Pit Development
Face Morphogenesis
Cellular Response To BMP Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Interneuron Axon Guidance
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
Regulation of RUNX2 expression and activity
Drugs
Diseases
GWAS
Erectile dysfunction (
30583798
)
Heel bone mineral density (
28869591
)
Hemoglobin levels (
32327693
)
Heel bone mineral density (
30598549
28869591
)
Morning vs. evening chronotype (
26835600
)
Interacting Genes
22 interacting genes:
ATXN1
CLK1
CTBP1
DLX5
HDAC1
HDAC2
MBD3
MSX2
MTA2
NCOR1
NCOR2
PPARD
RARA
RBBP4
RBPJ
RIDA
RUNX1
RUNX1T1
SERTAD1
SOX9
SRPK2
UBE2L6
9 interacting genes:
DLX2
HOXC8
MAGED1
MSX1
MSX2
NCOA2
SOX10
SOX8
SPEN
Entrez ID
23013
1749
HPRD ID
10230
02492
Ensembl ID
ENSG00000065526
ENSG00000105880
Uniprot IDs
Q96T58
P56178
Q53Y73
PDB IDs
1OW1
2RT5
4P6Q
2DJN
4RDU
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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