UBE2L6 and RNF25

Data Source:
BioGRID (two hybrid)

		UBE2L6	RNF25
Description		ubiquitin conjugating enzyme E2 L6	ring finger protein 25
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Nucleus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding NF-kappaB Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Phosphopantetheinylation Translesion Synthesis ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process	Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Male-pattern baldness ( 28196072)
Interacting Genes		40 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MID1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A	11 interacting genes: KCTD21 MEOX2 RELA TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2E2 UBE2E3 UBE2L6 UBE2U
Entrez ID		9246	64320
HPRD ID		04867	09737
Ensembl ID		ENSG00000156587	ENSG00000163481
Uniprot IDs		O14933	Q96BH1
PDB IDs		1WZV 1WZW 2KJH	2DAY 2DMF 5D1K 5D1L 5D1M
Enriched GO Terms of Interacting Partners?
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