CCT5 and ACTA1

Data Source:
HPRD (in vitro)

		CCT5	ACTA1
Description		chaperonin containing TCP1 subunit 5	actin alpha 1, skeletal muscle
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Exosome	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Dynactin Complex Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	MRNA 3'-UTR Binding Protein Binding ATP Binding G-protein Beta-subunit Binding Protein Folding Chaperone MRNA 5'-UTR Binding Beta-tubulin Binding Unfolded Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Response To Virus Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Striated Muscle Contraction
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy
GWAS		Metabolite levels ( 23823483) Pain ( 22956598)
Interacting Genes		20 interacting genes: ACTA1 ACTA2 ACTB CDC20 DUXAP9 ELP1 ERCC6 HDAC3 IMMT MCPH1 PDCL SUMO2 SUMO4 TBC1D17 TCP1 TERT THEG TP53 XRN1 ZNRD2	114 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		22948	58
HPRD ID		06468	00030
Ensembl ID		ENSG00000150753	ENSG00000143632
Uniprot IDs		B4DDU6 B4DX08 B4DYC8 B7ZAR1 E7ENZ3 E9PCA1 P48643 V9HW37	P68133
PDB IDs		5UYX 5UYZ 6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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