EIF4A1 and EIF4G2

Data Source:
HPRD (in vitro, in vivo)

		EIF4A1	EIF4G2
Description		eukaryotic translation initiation factor 4A1	eukaryotic translation initiation factor 4 gamma 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex Axon
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Viral Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Heart Development Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of Axon Extension Positive Regulation Of Dendritic Spine Development
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ISG15 antiviral mechanism
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2	13 interacting genes: C1QTNF9 CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL SUMO2
Entrez ID		1973	1982
HPRD ID		04030	09084
Ensembl ID		ENSG00000161960	ENSG00000110321
Uniprot IDs		P60842	P78344 Q2TU89
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW	3D3M 3L6A 4IUL
Enriched GO Terms of Interacting Partners?
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