EIF4A1 and UPF2

Data Source:
HPRD (two hybrid)

		EIF4A1	UPF2
Description		eukaryotic translation initiation factor 4A1	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Viral Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Diverticular disease ( 30177863)
Interacting Genes		13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		1973	26019
HPRD ID		04030	10405
Ensembl ID		ENSG00000161960	ENSG00000151461
Uniprot IDs		P60842	Q9HAU5
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW	1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
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