EIF4A1 and PLPPR4

Data Source:
HPRD (two hybrid)

		EIF4A1	PLPPR4
Description		eukaryotic translation initiation factor 4A1	phospholipid phosphatase related 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding	Phosphatidate Phosphatase Activity Lipid Phosphatase Activity
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Viral Process	Phospholipid Metabolic Process Signal Transduction Axonogenesis Phospholipid Dephosphorylation Inner Ear Development
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Lysosphingolipid and LPA receptors
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2	2 interacting genes: EIF4A1 FRA10AC1
Entrez ID		1973	9890
HPRD ID		04030	07425
Ensembl ID		ENSG00000161960	ENSG00000117600
Uniprot IDs		P60842	Q7Z2D5
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW
Enriched GO Terms of Interacting Partners?
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