EIF4A1 and FAM107A

Data Source:
BioGRID (two hybrid)

		EIF4A1	FAM107A
Description		eukaryotic translation initiation factor 4A1	family with sequence similarity 107 member A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome	Stress Fiber Nucleus Cytoplasm Focal Adhesion Actin Cytoskeleton Nuclear Speck Ruffle Membrane Neuron Projection Synapse
	Molecular Function	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding	Molecular_function Actin Binding Protein Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Viral Process	Regulation Of Cell Growth Cell Cycle Actin Filament Polymerization Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Regulation Of Actin Cytoskeleton Organization Cognition Actin Filament Bundle Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917)
Interacting Genes		13 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 PAIP1 PLPPR4 PRMT1 SUMO2 TNKS UCHL5 UPF2	58 interacting genes: AGMAT APPBP2 AUH AZI2 BEGAIN BIRC8 CALCOCO2 CANX CCDC125 CCDC136 CCDC57 CCDC85B CPSF3 DAPK1 EFEMP2 EFHC2 EIF4A1 ESRRG FKBP6 FSD2 GFM2 GOLGA6L9 HFM1 HOOK2 HSF2BP HSPA14 HSPD1 HTRA1 IQUB ITPRID2 KRT15 KRT19 KRT27 KRT40 KRTAP4-12 LDOC1 LZTS2 MEIOB MID2 MTREX MTUS2 NEXN NFKBID NINL PLSCR1 PNMA1 POMP PSMD6 RAB18 RINT1 RNLS SPATA22 TADA2A TRAF2 TRIM37 USHBP1 VIM WDR47
Entrez ID		1973	11170
HPRD ID		04030	09753
Ensembl ID		ENSG00000161960	ENSG00000168309
Uniprot IDs		P60842	A0A024R327 O95990 Q6IAM1
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW
Enriched GO Terms of Interacting Partners?
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