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EIF4A1 and FAM107A
Data Source:
BioGRID
(two hybrid)
EIF4A1
FAM107A
Description
eukaryotic translation initiation factor 4A1
family with sequence similarity 107 member A
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Membrane
Eukaryotic Translation Initiation Factor 4F Complex
Extracellular Exosome
Stress Fiber
Nucleus
Cytoplasm
Focal Adhesion
Actin Cytoskeleton
Nuclear Speck
Ruffle Membrane
Neuron Projection
Synapse
Molecular Function
RNA Cap Binding
RNA Binding
RNA Helicase Activity
Double-stranded RNA Binding
MRNA Binding
Translation Initiation Factor Activity
Helicase Activity
Protein Binding
ATP Binding
Translation Factor Activity, RNA Binding
Molecular_function
Actin Binding
Protein Binding
Biological Process
Cytoplasmic Translational Initiation
Translational Initiation
Viral Process
Regulation Of Cell Growth
Cell Cycle
Actin Filament Polymerization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Cellular Response To Nutrient Levels
Regulation Of Actin Cytoskeleton Organization
Cognition
Actin Filament Bundle Assembly
Negative Regulation Of Focal Adhesion Assembly
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Glucocorticoid Stimulus
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Copper
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Blood protein levels (
30072576
)
Night sleep phenotypes (
27126917
)
Interacting Genes
13 interacting genes:
EIF4G1
EIF4G2
EIF4G3
FAM107A
LIG4
MAPK6
PAIP1
PLPPR4
PRMT1
SUMO2
TNKS
UCHL5
UPF2
58 interacting genes:
AGMAT
APPBP2
AUH
AZI2
BEGAIN
BIRC8
CALCOCO2
CANX
CCDC125
CCDC136
CCDC57
CCDC85B
CPSF3
DAPK1
EFEMP2
EFHC2
EIF4A1
ESRRG
FKBP6
FSD2
GFM2
GOLGA6L9
HFM1
HOOK2
HSF2BP
HSPA14
HSPD1
HTRA1
IQUB
ITPRID2
KRT15
KRT19
KRT27
KRT40
KRTAP4-12
LDOC1
LZTS2
MEIOB
MID2
MTREX
MTUS2
NEXN
NFKBID
NINL
PLSCR1
PNMA1
POMP
PSMD6
RAB18
RINT1
RNLS
SPATA22
TADA2A
TRAF2
TRIM37
USHBP1
VIM
WDR47
Entrez ID
1973
11170
HPRD ID
04030
09753
Ensembl ID
ENSG00000161960
ENSG00000168309
Uniprot IDs
P60842
A0A024R327
O95990
Q6IAM1
PDB IDs
2G9N
2ZU6
3EIQ
5ZBZ
5ZC9
6ZMW
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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