CRYAA and MIP

Data Source:
HPRD (in vitro)

		CRYAA	MIP
Description		crystallin alpha A	major intrinsic protein of lens fiber
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity
	Biological Process	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Protein Stabilization Response To Stimulus	Lens Development In Camera-type Eye Water Transport Visual Perception Positive Regulation Of Cell Adhesion Response To Stimulus Protein Homotetramerization Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways			Passive transport by Aquaporins
Drugs			B-nonylglucoside
Diseases
GWAS		Age-related nuclear cataracts ( 33311586 24951543) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 28739976 27618452)	Axial length ( 24144296)
Interacting Genes		18 interacting genes: ALB BCL2L1 CRYAA2 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS GORASP2 HSPB1 HSPB2 LALBA MIP NTAQ1 SDCBP SPG21	47 interacting genes: AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1
Entrez ID		1409	4284
HPRD ID		00427	01098
Ensembl ID		ENSG00000160202	ENSG00000135517
Uniprot IDs		A0A140G945 P02489	P30301
PDB IDs		6T1R
Enriched GO Terms of Interacting Partners?
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