MIP and ATP6V0B

Data Source:
BioGRID (two hybrid)

		MIP	ATP6V0B
Description		major intrinsic protein of lens fiber	ATPase H+ transporting V0 subunit b
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Integral Component Of Membrane Apical Plasma Membrane	Vacuolar Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity	Transporter Activity Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Lens Development In Camera-type Eye Water Transport Visual Perception Positive Regulation Of Cell Adhesion Response To Stimulus Protein Homotetramerization Transmembrane Transport Gap Junction-mediated Intercellular Transport	Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport
Pathways		Passive transport by Aquaporins	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		B-nonylglucoside	Tiludronic acid
Diseases
GWAS		Axial length ( 24144296)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		47 interacting genes: AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1	28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG
Entrez ID		4284	533
HPRD ID		01098	04759
Ensembl ID		ENSG00000135517	ENSG00000117410
Uniprot IDs		P30301	E9PNL3 Q99437
PDB IDs
Enriched GO Terms of Interacting Partners?
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