CRYAA and HSPB2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CRYAA	HSPB2
Description		crystallin alpha A	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity
	Biological Process	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Protein Stabilization Response To Stimulus	Response To Unfolded Protein Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586 24951543) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 28739976 27618452)
Interacting Genes		18 interacting genes: ALB BCL2L1 CRYAA2 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS GORASP2 HSPB1 HSPB2 LALBA MIP NTAQ1 SDCBP SPG21	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		1409	3316
HPRD ID		00427	03712
Ensembl ID		ENSG00000160202	ENSG00000170276
Uniprot IDs		A0A140G945 P02489	A8KAH6 Q16082
PDB IDs		6T1R	6F2R
Enriched GO Terms of Interacting Partners?
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