BIK and ALG8

Data Source:
BioGRID (two hybrid)

		BIK	ALG8
Description		BCL2 interacting killer	ALG8 alpha-1,3-glucosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Endomembrane System Integral Component Of Membrane Mitochondrial Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Prostate cancer ( 25939597 21743057) Prostate cancer (SNP x SNP interaction) ( 22219177)	Depression in smokers ( 30219690) Tourette syndrome ( 30818990)
Interacting Genes		95 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ASB11 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 C4orf3 CD53 CD72 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A GPX8 GRM2 INSIG2 KCNN4 MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM PBX3 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 REEP4 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 TANK TMBIM1 TMEM107 TMEM11 TMEM14B TMEM14C TMEM199 TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBE2D1 UBIAD1 VAMP3 VAMP5 ZFPL1	12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		638	79053
HPRD ID		04547	10480
Ensembl ID		ENSG00000100290	ENSG00000159063
Uniprot IDs		A0A024R4X6 Q13323	A0A024R5K5 Q9BVK2
PDB IDs		2IPE
Enriched GO Terms of Interacting Partners?
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